I'm attempting to modify very large matrices (single, 50e3 x 50e3), which don't make sense to load into the memory. I was wondering what you could recommend me as a data handling strategy? I thought ideally I could always load a let us say 100x100 square modify it and write it back. My working machine uses a SSD connected via M2 so it should be relatively speedy (however of course not nearly as fast as RAM). What suggestions do you have?