SimBiology insulindemo does not load variants in the parameters

Hi all I am new in SimBiology and I am trying to run the insulindemo example following the steps in this link: https://es.mathworks.com/help/simbio/examples/simulating-the-glucose-insulin-response.html When I modify a simple parameter (specifically "StartTime" within the 'Single Meal' object, by replacing '0' by '2', or whatever) and I restart the simulation to load the new values, the plasma glucose results do not reflect the new start time, but instead they are completely flat. Am I doing anything wrong? Thanks in advance. Manuel J.

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Answer 1

[Arthur Goldsipe]

Hi Manuel,

Are you using R2017a? There is a bug in this release that affects this particular demo. Specifically, when a dose and an event occur at the same time, only the dose takes effect. In this particular demo, this means that any meals that occur after time 0 will not get applied correctly to the model. Can you try this example in R2016b or in the R2017b pre-release and see if the problem is addressed?

If you don't have access to a different release, I'm not sure what to recommend. There might be a way to change the model to work around the bug, but I would have to think about that.

-Arthur

[Manuel J. Abaldea]

Hi Arthur,

Yes, I was using R2017a. It works perfectly using R2016b.

Thank you so much for your advice and help.

Answer 2

[Manuel J. Abaldea]

Dear all,

I would like to simulate a Type 1 diabetic patient by using the Cobelli's Model. In the insulin model example, I have the next variants: Type2, low/high insulin sensitivity, low/high beta cell responsivity. Which of them refers to a Type1 diabetic patient?

Another question, when I try to run the insulin demo example I don't get to simulate (in none of the variants) an open-loop controlled subject. Is it possible to provide the amount of exogenous insulin for each meal?

Thank you.