Administer simultaneously different doses to different compartment in Simbiology

Is it possible to administer two different dose objects (each one one to a different compartment) simultaneously using sbiosimulate in Simbiology? Or do I need to create a simulation scenario combining them. If so, could you share some code?

Thanks a lot!

Zinnia

Answer 1

[Jeremy Huard]

Hi Zinnia,

yes, you can administer different doses with different targets at the same time during a simulation. You can do this with sbiosimulate or a SimFunction.

Here is an example with sbiosimulate:

% Create a two compartment model
pkm = PKModelDesign;
pkc= addCompartment(pkm, 'Central', 'DosingType', 'Bolus', ...
                     'EliminationType', 'linear-clearance', ...
                     'HasResponseVariable', true);
pkp = addCompartment(pkm, 'Peripheral', 'DosingType', 'Bolus', ...
                     'EliminationType', 'linear-clearance');
modelObj = pkm.construct;

% Create dose
dC = adddose(modelObj,'DoseC');
dC.Amount = 10;
dC.TargetName = 'Central.Drug_Central';

dP = adddose(modelObj,'DoseP');
dP.Amount = 20;
dP.TargetName = 'Peripheral.Drug_Peripheral';
dP.Interval = 5;
dP.RepeatCount = 1;

% Run Simulation
results = sbiosimulate(modelObj,[dC,dP]);

% Plot result
sbioplot(results);
set(gca, 'XLimitMethod','padded','YLimitMethod','padded');
grid on;

I hope it helps.

Best regards,

Jérémy

[Zinnia Parra-Guillen]

Thanks a lot Jérémy! I was wrongly including the dose objects between quotes in the sbiosimulate function, that was the problem.

Best,

Zinnia

Answer 2

[Syed Imran Ali shah]

Modeling the Pharmacokinetic Effect of Phenobarbital on Neonates (using SimBiology Desktop)

Answer 3

[Syed Imran Ali shah]

Accessing PK library models from code

Answer 4

[Syed Imran Ali shah]

https://www.mathworks.com/matlabcentral/answers/428116-do-simfunctions-support-parameterized-dosing?s_tid=answers_rc1-1_p1_Topic