MathWorks - Mobile View
  • Sign In to Your MathWorks AccountSign In to Your MathWorks Account
  • Access your MathWorks Account
    • My Account
    • My Community Profile
    • Link License
    • Sign Out
  • Products
  • Solutions
  • Academia
  • Support
  • Community
  • Events
  • Get MATLAB
MathWorks
  • Products
  • Solutions
  • Academia
  • Support
  • Community
  • Events
  • Get MATLAB
  • Sign In to Your MathWorks AccountSign In to Your MathWorks Account
  • Access your MathWorks Account
    • My Account
    • My Community Profile
    • Link License
    • Sign Out

Videos and Webinars

  • MathWorks
  • Videos
  • Videos Home
  • Search
  • Videos Home
  • Search
  • Contact sales
  • Trial software
  Register to watch video
  • Description
  • Related Resources

Application of SimBiology to PK/PD, Systems Pharmacology & Dose Prediction Problems

Dr. Neil Benson, Xenologiq Ltd

The right target, dose and regimen are critical to success in drug discovery. Thus, building the best possible understanding of these variables as early as possible in the drug discovery process is highly beneficial.

This presentation disusses the use of pharmacokinetic/pharmacodynamic modeling techniques to extract parameter estimates from multiple species, and the application of allometric scaling principles to extrapolate human PK parameters and dose for a novel biological. We also discuss the use of a systems pharmacology approach to investigate optimal targets and drug doses in the nerve growth factor pathway.  These examples demonstrate that translational modeling using SimBiology can help focus resources by indicating the target, approaches and doses most likely to succeed.   

About the Presenter: Neil Benson

Neil has 20 years’ experience working in the pharmaceutical industry at SmithKline Beecham, Pfizer and Xenologiq Ltd. He has held a number of senior leadership positions, most recently as Head of systems pharmacology at Pfizer, Sandwich. He was awarded the Pfizer Upjohn award for innovation in developing dose prediction methodology. In 2011, he founded Xenologiq Ltd, a consultancy company interested in reducing PKPD and systems pharmacology approaches to effective practice in drug discovery. He has extensive experience of using modeling and simulation to address questions of critical importance in drug discovery including; clinical dose prediction, optimal target identification and biomarker selection and has authored ~ 30 papers and patents. Educated at the University of East Anglia (UK) and the University of Lund (Sweden), Neil has a First class Honours degree and a PhD in physical biochemistry.  

Recorded: 14 Mar 2013

Related Products

  • SimBiology

Feedback

Featured Product

SimBiology

  • Request Trial
  • Get Pricing

Up Next:

46:51
Using Systems Pharmacology Modeling Approaches to Guide...

Related Videos:

26:17
Modeling Synthetic Biology Systems with MATLAB and...
2:45
Accelerating Drug Discovery and Development with SimBiology
25:49
Modeling Biology with SimBiology: An Introduction for iGEM...
52:52
Population Pharmacokinetic Modeling Using Nonlinear...

View more related videos

MathWorks - Domain Selector

Select a Web Site

Choose a web site to get translated content where available and see local events and offers. Based on your location, we recommend that you select: .

Select web site

You can also select a web site from the following list:

How to Get Best Site Performance

Select the China site (in Chinese or English) for best site performance. Other MathWorks country sites are not optimized for visits from your location.

Americas

  • América Latina (Español)
  • Canada (English)
  • United States (English)

Europe

  • Belgium (English)
  • Denmark (English)
  • Deutschland (Deutsch)
  • España (Español)
  • Finland (English)
  • France (Français)
  • Ireland (English)
  • Italia (Italiano)
  • Luxembourg (English)
  • Netherlands (English)
  • Norway (English)
  • Österreich (Deutsch)
  • Portugal (English)
  • Sweden (English)
  • Switzerland
    • Deutsch
    • English
    • Français
  • United Kingdom (English)

Asia Pacific

  • Australia (English)
  • India (English)
  • New Zealand (English)
  • 中国
    • 简体中文Chinese
    • English
  • 日本Japanese (日本語)
  • 한국Korean (한국어)

Contact your local office

  • Contact sales
  • Trial software

Explore Products

  • MATLAB
  • Simulink
  • Student Software
  • Hardware Support
  • File Exchange

Try or Buy

  • Downloads
  • Trial Software
  • Contact Sales
  • Pricing and Licensing
  • How to Buy

Learn to Use

  • Documentation
  • Tutorials
  • Examples
  • Videos and Webinars
  • Training

Get Support

  • Installation Help
  • Answers
  • Consulting
  • License Center
  • Contact Support

About MathWorks

  • Careers
  • Newsroom
  • Social Mission
  • Contact Sales
  • About MathWorks

MathWorks

Accelerating the pace of engineering and science

MathWorks is the leading developer of mathematical computing software for engineers and scientists.

Discover…

  • Select a Web Site United States
  • Patents
  • Trademarks
  • Privacy Policy
  • Preventing Piracy
  • Application Status
  • Modern Slavery Act Transparency Statement

© 1994-2021 The MathWorks, Inc.

  • Facebook
  • Twitter
  • Instagram
  • YouTube
  • LinkedIn
  • RSS

Join the conversation

This website uses cookies to improve your user experience, personalize content and ads, and analyze website traffic.  By continuing to use this website, you consent to our use of cookies.  Please see our Privacy Policy to learn more about cookies and how to change your settings.