Compute Position Weight Matrix (PWM) and display SequenceLogo in terms of frequency
main executing reference usage: operationMain.m
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main executing reference usage: usage_PWM.m
[Demo 1]: PWM (Position Weight Matrix) and Information Content
usage_PWM.m
The objective is to compute the PWM, and report the consensus.
Sample output:
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String index: 1 2 3 4 5 6 7
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C : 0.00 0.10 0.05 0.10 0.00 0.05 0.90
T : 0.10 0.85 0.05 0.80 0.80 0.00 0.05
A : 0.05 0.00 0.00 0.05 0.20 0.05 0.05
G : 0.85 0.05 0.90 0.05 0.00 0.90 0.00
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H : 0.75 0.75 0.57 1.02 0.72 0.57 0.57
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I : 1.25 1.25 1.43 0.98 1.28 1.43 1.43
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Total I : 9.05
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Mean I : 1.29
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The consensus is GTGTTGC.
Note:
The sequencelogo feature does not use the bioinformatics toolbox.
Caveat: The y-axis of the sequencelogo is in terms of frequency. It is not perfect, but it serves as a basic visual guide in the absence of having the seqlogo inbuilt.
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main executing reference usage: usage_computeProbabilityOfSequenceGivenPWM.m
[Demo 2]: Best Matches on PWM
usage_computeProbabilityOfSequenceGivenPWM.m
The objective is to illustrate Best Matches on PWM with determination of locations.
* To verify results, save results in targetFile and run usage_PWM.m with
targetFile = 'inputFromBestMatchFromDemo2.txt';
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* Caveat: For educational reference only.
If the reference demo has a more elegant presentation, please do not hesitate to suggest and send feedback to author.
Email: promethevx@yahoo.com.
Thank you.
Regards,
Michael Chan JT
Cite As
Michael Chan (2024). Compute Position Weight Matrix (PWM) and display SequenceLogo in terms of frequency (https://www.mathworks.com/matlabcentral/fileexchange/29363-compute-position-weight-matrix-pwm-and-display-sequencelogo-in-terms-of-frequency), MATLAB Central File Exchange. Retrieved .
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Version | Published | Release Notes | |
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1.0.0.0 |