Different dilution effect on the kinetics of a time course
Luis B. Walter
on 15 Jun 2024
Latest activity Reply by Arthur Goldsipe
on 17 Jun 2024
Hi to everyone!
To simplify the explanation and the problem, I simulated the kinetics of an irreversible first-order reaction, A -> B. I implemented it in two independent compartments, R and P. I simulated the effect of a dilution in R by doubling at t= 0,1 the R volume. I programmed in P that, at t = 0.1, the instantaneous concentration of A and B would be reduced by half. I am sending an attach with the implementation of these simulations in the Simbiology interface.
When the simulations of the two compartments are plotted, it can be seen that the responses are not equal. That is, from t = 0.1 s, the reaction follow an exponential function in R with half of the initial amplitude and half of the initial value of k1. That is, the relaxation time is doubled. Meanwhile, in P, from t = 0.1, the reaction follows exponential kinetics with half the amplitude value but maintaining the initial value of k = 10. Without a doubt, the correct simulation is the latter (compartment P) where only the effect is observed in the amplitude and not in the relaxation time. Could you tell me what the error is that makes these kinetics that should be equal not be?
Thank you in advance!
Luis B.
1 Comment
Time Descending
Please try to post each question only once. I personally try to make sure SimBiology questions are answered, but it can sometimes take a couple of business days.
Posting this as a question also makes more sense to me than posting it as a discussion. That way, we can mark one answer as the best answer, rather than having to read through all the discussion to figure that out.
-Arthur
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