The idea is to use a data type that Simulink supports in place of the pointer. Since pointers are 64 bits long, use a Simulink data type that is 64 bits long. Then, in the external C code, convert the datatype used by Simulink to/form a unit16*. The best approach is to use a 64-bit integer in Simulink, since most C compilers will allow you to cast an integer to a pointer. But this requires the Fixed Point Toolbox. If you have a license for this, the set the data type of the variable to be ufix(64). If you don't have a Fixed Point license, then you can select a built-in Simulink data type that is 64 bits long, for example double or uint32. C compilers won't let you cast these variables to/from a pointer, so you will need to create a temporary variable in your external code that is of type uint16* and then memcpy between the variable in the Simulink bus and the local uint16* variable.