finding a change in a matrix

Hi,
I have a matrix in which each column is usually constant but sometimes the value changes. Is there a way to figure out where the change occurs without running loops? for example A=[ 1 2 3 4 5; 1 2 3 4 5; 1 2 2 4 5; 1 2 2 4 5]
is it possible to compute that observation A(3,3) has changed?

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